Prince Harry and Meghan Markle are set to make their first post-Oprah public appearance on May 2, when they step out for Global Citizen’s VAX Live concert—the aim of which is to ‘reunite the world’ by inspiring public confidence in COVID-19 vaccines and to urge world leaders to make the vaccines available to all.

They’ll be joined by President Joe Biden, First Lady Jill Biden, and Vice-President Kamala Harris as Los Angeles’s So-Fi Stadium for the event, hosted by Selena Gomez, which will be taped and subsequently broadcast on May 8.

Other guests will include Chrissy Teigen, Ben Affleck, Gayle King and David Letterman, with performances by Jennifer Lopez, H.E.R. and the Foo Fighters.

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The Duke and Duchess of Sussex will be appearing in their roles as campaign chairs of VAX Live, and will be delivering a message on behalf of global vaccine equity.

In a statement, Harry and Meghan said, “Over the past year, our world has experienced pain, loss and struggle— together. Now we need to recover and heal—together. We can’t leave anybody behind.

“We will all benefit, we will all be safer, when everyone everywhere has equal access to the vaccine. We must pursue equitable vaccine distribution, and in that, restore faith in our common humanity. This mission couldn’t be more critical or important.”

The Sussexes are campaign chairs of #VaxLive and will deliver an urgent message for vaccine equity during the event. They have also led a coordinated drive across the private sector to raise critical funds for the vaccine-sharing program #COVAX.

The couple share in a statement:

— Omid Scobie (@scobie) April 27, 2021

Royal reporter Omid Scobie points out, “Right now, only 0.1% of worldwide doses have been administered in low-income countries, leaving millions vulnerable.”

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Meanwhile, Selena Gomez said she is “honored” to be part of the event, adding, “This is a historic moment to encourage people around the world to take the COVID-19 vaccine when it becomes available to them, call on world leaders to share vaccine doses equitably and to bring people together for a night of music in a way that hasn’t felt possible in the past year.”

Global Citizen’s co-founder and CEO Hugh Evans previously told People, ” There is a light at the end of this tunnel, but getting vaccines to everyone, everywhere regardless of who they are or where they are from, is key to ensuring the end of this pandemic around the world.

“We must all unite to get back on track to eradicating extreme poverty.”

Next up, here’s why the royal women—the Queen, Kate, and Camilla—wore colorless jewels to Prince Philip’s funeral.